Contribution of syndecan-4 genetic variants to hypertension, the TAMRISK study.

ABSTRACT:

Background

A human syndecan-4 genetic variant (rs1981429) has previously been associated with lean tissue mass and intra-abdominal fat, and SNP rs4599 with resting energy expenditure in healthy early pubertal children. These variations could thus cause overweight and hypothetically lead to hypertension. Their association with body mass index and blood pressure was therefore studied in a Finnish cohort of adults.

Methods

The data was collected from the Tampere adult population cardiovascular risk study (TAMRISK). A total of 279 cases with hypertension and/or coronary artery disease (CAD), and 488 non-hypertensive healthy controls were selected from a Finnish periodic health examination 50-year-old cohort. Information was available also from their 45-year examination. DNA was

SUBMITTER: Kunnas T 

PROVIDER: S-EPMC4247658 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature