Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer.

ABSTRACT:

Background

The ErbB family consists of four proteins including (EGFR)/ErbB1, ErbB2, ErbB3, and ErbB4, and plays a crucial role in the promotion of multiple tumorigenic processes. In addition to the traditional pathways of EGFR signaling, EGFR translocates to the nucleus and acts as a transcription factor in the proliferation of cancer cells. Heregulin is known as both an ErbB3 and an ErbB4 ligand. This study aimed to investigate the expression of heregulin and its relevant EGFR family members as well as their phosphorylated forms in human colorectal cancer (CRC) tissues and to determine the relationship between their expression and clinicopathological factors including patient prognosis.

Methods

We analyzed the effects of exogenous heregulin on ErbB2, ErbB3 and ErbB4 phospho

SUBMITTER: Mitsui K 

PROVIDER: S-EPMC4247672 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature