Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model.

ABSTRACT:

Background

All-trans retinoic acid (ATRA, tretinoin) is a vitamin A derivative commonly used in the treatment of diverse conditions ranging from cancer to acne. In a fraction of predisposed individuals, the administration of ATRA is accompanied by variety of adverse metabolic effects, particularly by the induction of hyperlipidemia. We have previously derived a minimal congenic SHR.PD-(D8Rat42-D8Arb23)/Cub (SHR-Lx) strain sensitive to ATRA-induced increase of triacylglycerols and cholesterol under condition of high-sucrose diet. SHR-Lx differs only by 7 genes of polydactylous rat (PD/Cub) origin from its spontaneously hypertensive rat (SHR) progenitor strain.

Methods

Adult male rats of SHR and SHR-Lx strains were fed standard diet (STD) and experimental groups were subsequen

SUBMITTER: Krupkova M 

PROVIDER: S-EPMC4247747 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature