Interactions of Papua New Guinea medicinal plant extracts with antiretroviral therapy.

ABSTRACT:

Ethnopharmacological relevance

A substantial proportion of the population in Papua New Guinea (PNG) lives with human immunodeficiency virus (HIV). Treatment requires lifelong use of antiretroviral therapy (ART). The majority of people in PNG use traditional medicines (TM) derived from plants for all types of health promotions. Consequently, there is a concern that herb-drug interactions may impact the efficacy of ART. Herb-drug, or drug-drug, interactions occur at the level of metabolism through two major mechanisms: enzyme induction or enzyme inhibition. In this study, extracts of commonly-used medicinal plants from PNG were screened for herb-drug interactions related to cytochrome P450s (CYPs).

Materials and methods

Sixty nine methanol extracts of TM plants were screened f

SUBMITTER: Larson EC 

PROVIDER: S-EPMC4247785 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature