Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese.

ABSTRACT:

Background

Manganese (Mn) is an essential element that can become neurotoxic through various exposure windows over the lifespan. While there is clear evidence of Mn neurotoxicity in pediatric and adult occupational populations, little is known about effects in the elderly who may exhibit enhanced susceptibilities due to compromised physiology compared to younger adults. In the province of Brescia, Italy, the Valcamonica area has been the site of three ferroalloy plants operating from 1902 to 2001. Metal emissions of Mn and to a lesser extent lead (Pb) have impacted the surrounding environment, where a high prevalence of Parkinsonism was previously observed. This study aimed to assess neurocognitive and motor functions in healthy elderly subjects residing for most of their lifetime

SUBMITTER: Lucchini RG 

PROVIDER: S-EPMC4247810 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature