Optimization of white-matter-nulled magnetization prepared rapid gradient echo (MP-RAGE) imaging.

ABSTRACT:

Purpose

To optimize the white-matter-nulled (WMn) Magnetization Prepared Rapid Gradient Echo (MP-RAGE) sequence at 7 Tesla (T), with comparisons to 3T.

Methods

Optimal parameters for maximizing signal-to-noise ratio (SNR) efficiency were derived. The effect of flip angle and repetition time (TR) on image blurring was modeled using simulations and validated in vivo. A novel two-dimensional (2D) -centric radial fan beam (RFB) k-space segmentation scheme was used to shorten scan times and improve parallel imaging. Healthy subjects as well as patients with multiple sclerosis and tremor were scanned using the optimized protocols.

Results

Inversion repetition times (TS) of 4.5 s and 6 s were found to yield the highest SNR efficiency for WMn MP-RAGE at 3T and 7T, respectivel

SUBMITTER: Saranathan M 

PROVIDER: S-EPMC4247820 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature