Combined effect of established BMI loci on obesity-related traits in an Algerian population sample.

ABSTRACT:

Background

Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and the obesity risk in an Algerian population sample, the ISOR study.

Results

We found that each additional risk allele in the GPS was associated with an increment in the mean [95% CI] for BMI of 0.15 [0.06 - 0.24] kg/m2 (p = 0.001). Although the GPS was also associated with higher waist (p = 0.02) and hip (p = 0.02) circumferences, these associations were in fact driven by BMI. The GPS was also associated with an 11% higher risk of obesity (OR [95%CI] = 1.11 [1.05 - 1.18], p = 0.0004).

Conclusions

Our data showed that a GPS

SUBMITTER: Badsi MN 

PROVIDER: S-EPMC4247883 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature