Interleukin-6 and interleukin-10 gene polymorphisms and recurrent pregnancy loss in Romanian population.

ABSTRACT:

Background

Approximately 10-14% of the clinically acknowledged pregnancies end with spontaneous abortion at Caucasian population. Possible immunologic causes of recurrent miscarriages have been extensively researched. The change in the cytokines balance synthesis in favor of those synthesized by Th2 cells with an increase of interleukin 6 (IL6) and interleukin10 (IL10) secretion is considered essential for maintaining a normal pregnancy.

Objective

The study objective was to establish an association between interleukin 6 and 10 genes polymorphisms and etiology of recurrent pregnancy loss.

Materials and methods

The genetic polymorphism of interleukin 6 and 10 genes were studied by PCR-RFLP in the DNA of 69 women with recurrent pregnancy loss and 64 control women with at

SUBMITTER: L Bohiltea C 

PROVIDER: S-EPMC4248146 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature