Ontology highlight
ABSTRACT:
SUBMITTER: Fong N
PROVIDER: S-EPMC4248296 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Genes & development 20141201 23
Alternative splicing modulates expression of most human genes. The kinetic model of cotranscriptional splicing suggests that slow elongation expands and that fast elongation compresses the "window of opportunity" for recognition of upstream splice sites, thereby increasing or decreasing inclusion of alternative exons. We tested the model using RNA polymerase II mutants that change average elongation rates genome-wide. Slow and fast elongation affected constitutive and alternative splicing, frequ ...[more]