Is there a new dawn for selective mineralocorticoid receptor antagonism?

ABSTRACT:

Purpose of review

Aldosterone and the mineralocorticoid receptor contribute to resistant hypertension and cardiovascular mortality, and mineralocorticoid receptor antagonists effectively reduce these complications. Their use is limited in certain populations with a higher risk of hyperkalemia or renal dysfunction. This review will highlight recent developments in extra-renal mineralocorticoid receptor research and the development of novel mineralocorticoid receptor antagonists.

Recent findings

Tissue-specific knockout-out models provide definitive evidence that the vascular mineralocorticoid receptor directly contributes to hypertension and vascular remodeling, independent of renal effects. Several nonsteroidal mineralocorticoid receptor antagonists are in preclinical develo

SUBMITTER: Luther JM 

PROVIDER: S-EPMC4248353 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature