Familial occurrence and heritable connective tissue disorders in cervical artery dissection.

ABSTRACT:

Objective

In a large series of patients with cervical artery dissection (CeAD), a major cause of ischemic stroke in young and middle-aged adults, we aimed to examine frequencies and correlates of family history of CeAD and of inherited connective tissue disorders.

Methods

We combined data from 2 large international multicenter cohorts of consecutive patients with CeAD in 23 neurologic departments participating in the CADISP-plus consortium, following a standardized protocol. Frequency of reported family history of CeAD and of inherited connective tissue disorders was assessed. Putative risk factors, baseline features, and 3-month outcome were compared between groups.

Results

Among 1,934 consecutive patients with CeAD, 20 patients (1.0%, 95% confidence interval: 0.6%-1

SUBMITTER: Debette S 

PROVIDER: S-EPMC4248448 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature