Brain-Derived Neurotrophic Factor in children with Autism Spectrum Disorder.

ABSTRACT:

Background

Autism Spectrum Disorder (ASD) is a complex neurobehavioral syndrome with no known biomarker so far for early detection. It has been challenging, both to classify typical autism and associate a suitable biomarker with clinical phenotype spectrum. Brain-derived neurotrophic factor (BDNF) has emerged as a key neurotrophin regulating synaptic plasticity, neuronal differentiation and survival.

Purpose

Recently, BDNF depletion is reported in neurodegenerative as well as in psychiatric disorders, associated with severity of neurological dysfunction. Role of BDNF as a biomarker in ASD is gaining significance. Pre-clinical results have linked BDNF depletion in autism and mental retardation, however, with conflicting findings.

Methods

In view of this, a preliminary

SUBMITTER: Kasarpalkar NJ 

PROVIDER: S-EPMC4248479 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature