Impact of clade, geography, and age of the epidemic on HIV-1 neutralization by antibodies.

ABSTRACT:

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Neutralizing antibodies (nAbs) are a high priority for vaccines that aim to prevent the acquisition of HIV-1 infection. Vaccine effectiveness will depend on the extent to which induced antibodies neutralize the global diversity of circulating HIV-1 variants. Using large panels of genetically and geographically diverse HIV-1 Env-pseudotyped viruses and chronic infection plasma samples, we unambiguously show that cross-clade nAb responses are commonly induced in response to infection by any virus clade. Nonetheless, neutralization was significantly greater when the plasma clade matched the clade of the virus being tested. This within-clade advantage was diminished in older, more-diverse epidemics in southern Africa, the United States, and Europe compared to more recent epi

SUBMITTER: Hraber P 

PROVIDER: S-EPMC4248897 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature