Variation of the specificity of the human antibody responses after tick-borne encephalitis virus infection and vaccination.

ABSTRACT:

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Tick-borne encephalitis (TBE) virus is an important human-pathogenic flavivirus endemic in large parts of Europe and Central and Eastern Asia. Neutralizing antibodies specific for the viral envelope protein E are believed to mediate long-lasting protection after natural infection and vaccination. To study the specificity and individual variation of human antibody responses, we developed immunoassays with recombinant antigens representing viral surface protein domains and domain combinations. These allowed us to dissect and quantify antibody populations of different fine specificities in sera of TBE patients and vaccinees. Postinfection and postvaccination sera both displayed strong individual variation of antibody titers as well as the relative proportions of antibodies

SUBMITTER: Jarmer J 

PROVIDER: S-EPMC4248988 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature