Role of Mason-Pfizer monkey virus CA-NC spacer peptide-like domain in assembly of immature particles.

ABSTRACT:

Unlabelled

The hexameric lattice of an immature retroviral particle consists of Gag polyprotein, which is the precursor of all viral structural proteins. Lentiviral and alpharetroviral Gag proteins contain a peptide sequence called the spacer peptide (SP), which is localized between the capsid (CA) and nucleocapsid (NC) domains. SP plays a critical role in intermolecular interactions during the assembly of immature particles of several retroviruses. Published models of supramolecular structures of immature particles suggest that in lentiviruses and alpharetroviruses, SP adopts a rod-like six-helix bundle organization. In contrast, Mason-Pfizer monkey virus (M-PMV), a betaretrovirus that assembles in the cytoplasm, does not contain a distinct SP sequence, and the CA-NC connecting re

SUBMITTER: Strohalmova-Bohmova K 

PROVIDER: S-EPMC4249148 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature