Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R.

ABSTRACT: During a study to investigate the evolution of ampicillin resistance in Enterococcus faecium, we observed that a number of E. faecium strains, mainly from the recently described subclade A2, showed PBP5 sequences in between PBP5-S and PBP5-R. These hybrid PBP5-S/R patterns reveal a progression of amino acid changes from the S form to the R form of this protein; however, these changes do not strictly correlate with changes in ampicillin MICs.

SUBMITTER: Pietta E 

PROVIDER: S-EPMC4249377 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature