A HIF-1 network reveals characteristics of epithelial-mesenchymal transition in acute promyelocytic leukemia.

ABSTRACT:

Background

Acute promyelocytic leukemia (APL) is a sub-type of acute myeloid leukemia (AML) characterized by a block of myeloid differentiation at the promyelocytic stage and the predominant t(15:17) chromosomal translocation. We have previously determined that cells from APL patients show increased expression of genes regulated by hypoxia-inducible transcription factors (HIFs) compared to normal promyelocytes. HIFs regulate crucial aspects of solid tumor progression and are currently being implicated in leukemogenesis.

Methods

To investigate the contribution of hypoxia-related signaling in APL compared to other AML sub-types, we reverse engineered a transcriptional network from gene expression profiles of AML patients' samples, starting from a list of direct target genes of

SUBMITTER: Percio S 

PROVIDER: S-EPMC4249615 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature