Zebrafish prion protein PrP2 controls collective migration process during lateral line sensory system development.

ABSTRACT: Prion protein is involved in severe neurodegenerative disorders but its physiological role is still in debate due to an absence of major developmental defects in knockout mice. Previous reports in zebrafish indicate that the two prion genes, PrP1 and PrP2, are both involved in several steps of embryonic development thus providing a unique route to discover prion protein function. Here we investigate the role of PrP2 during development of a mechano-sensory system, the posterior lateral line, using morpholino knockdown and PrP2 targeted inactivation. We confirm the efficiency of the translation blocking morpholino at the protein level. Development of the posterior lateral line is altered in PrP2 morphants, including nerve axonal outgrowth and primordium migration defects. Reduced neuromast d

SUBMITTER: Huc-Brandt S 

PROVIDER: S-EPMC4249873 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature