The Rapalogue, CCI-779, improves salivary gland function following radiation.

ABSTRACT: The standard of care for head and neck cancer typically includes surgical resection of the tumor followed by targeted head and neck radiation. However depending on tumor location and stage, some cases may not require surgical resection while others may be treated with chemoradiation. Unfortunately, these radiation treatments cause chronic negative side effects for patients. These side effects are associated with damage to surrounding normal salivary gland tissue and include xerostomia, changes in taste and malnutrition. The underlying mechanisms of chronic radiation-induced salivary gland dysfunction are unknown, however, in rodent models persistently elevated proliferation is correlated with reduced stimulated salivary flow. The rapalogue, CCI-779, has been used in other cell systems to i

SUBMITTER: Morgan-Bathke M 

PROVIDER: S-EPMC4249875 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature