The circadian regulation of sleep: impact of a functional ADA-polymorphism and its association to working memory improvements.

ABSTRACT: Sleep is regulated in a time-of-day dependent manner and profits working memory. However, the impact of the circadian timing system as well as contributions of specific sleep properties to this beneficial effect remains largely unexplored. Moreover, it is unclear to which extent inter-individual differences in sleep-wake regulation depend on circadian phase and modulate the association between sleep and working memory. Here, sleep electroencephalography (EEG) was recorded during a 40-h multiple nap protocol, and working memory performance was assessed by the n-back task 10 times before and after each scheduled nap sleep episode. Twenty-four participants were genotyped regarding a functional polymorphism in adenosine deaminase (rs73598374, 12 G/A-, 12 G/G-allele carriers), previously associ

SUBMITTER: Reichert CF 

PROVIDER: S-EPMC4249976 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature