Resveratrol enhances palmitate-induced ER stress and apoptosis in cancer cells.

ABSTRACT:

Background

Palmitate, a saturated fatty acid (FA), is known to induce toxicity and cell death in various types of cells. Resveratrol (RSV) is able to prevent pathogenesis and/or decelerate the progression of a variety of diseases. Several in vitro and in vivo studies have also shown a protective effect of RSV on fat accumulation induced by FAs. Additionally, endoplasmic reticulum (ER) stress has recently been linked to cellular adipogenic responses. To address the hypothesis that the RSV effect on excessive fat accumulation promoted by elevated saturated FAs could be partially mediated by a reduction of ER stress, we studied the RSV action on experimentally induced ER stress using palmitate in several cancer cell lines.

Principal findings

We show that, unexpectedly, RSV prom

SUBMITTER: Rojas C 

PROVIDER: S-EPMC4250062 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature