Interference-mediated synaptonemal complex formation with embedded crossover designation.

ABSTRACT: Biological systems exhibit complex patterns at length scales ranging from the molecular to the organismic. Along chromosomes, events often occur stochastically at different positions in different nuclei but nonetheless tend to be relatively evenly spaced. Examples include replication origin firings, formation of chromatin loops along chromosome axes and, during meiosis, localization of crossover recombination sites ("crossover interference"). We present evidence in the fungus Sordaria macrospora that crossover interference is part of a broader pattern that includes synaptonemal complex (SC) nucleation. This pattern comprises relatively evenly spaced SC nucleation sites, among which a subset are crossover sites that show a classical interference distribution. This pattern ensures that SC fo

SUBMITTER: Zhang L 

PROVIDER: S-EPMC4250137 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature