Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Background

Observational studies of the relationship between hyperuricemia and the incidence of hypertension are controversial. We conducted a systematic review and meta-analysis to assess the association and consistency between uric acid levels and the risk of hypertension development.

Methods

We searched MEDLINE, EMBASE, CBM (Chinese Biomedicine Database) through September 2013 and reference lists of retrieved studies to identify cohort studies and nested case-control studies with uric acid levels as exposure and incident hypertension as outcome variables. Two reviewers independently extracted data and assessed study quality using Newcastle-Ottawa Scale. Extracted information included study design, population, definition of hyperuricemia and hypertension, number of inciden

SUBMITTER: Wang J 

PROVIDER: S-EPMC4250178 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature