Coverage of protein domain families with structural protein-protein interactions: current progress and future trends.

ABSTRACT: Protein interactions have evolved into highly precise and regulated networks adding an immense layer of complexity to cellular systems. The most accurate atomistic description of protein binding sites can be obtained directly from structures of protein complexes. The availability of structurally characterized protein interfaces significantly improves our understanding of interactomes, and the progress in structural characterization of protein-protein interactions (PPIs) can be measured by calculating the structural coverage of protein domain families. We analyze the coverage of protein domain families (defined according to CDD and Pfam databases) by structures, structural protein-protein complexes and unique protein binding sites. Structural PPI coverage of currently available protein fami

SUBMITTER: Goncearenco A 

PROVIDER: S-EPMC4250425 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature