Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients.

ABSTRACT: Acetaminophen (APAP)-induced acute liver failure (ALF) remains a major clinical problem. Although a majority of patients recovers after severe liver injury, a subpopulation of patients proceeds to ALF. Bile acids are generated in the liver and accumulate in blood during liver injury, and as such, have been proposed as biomarkers for liver injury and dysfunction. The goal of this study was to determine whether individual bile acid levels could determine outcome in patients with APAP-induced ALF (AALF). Serum bile acid levels were measured in AALF patients using mass spectrometry. Bile acid levels were elevated 5-80-fold above control values in injured patients on day 1 after the overdose and decreased over the course of hospital stay. Interestingly, glycodeoxycholic acid (GDCA) was signific

SUBMITTER: Woolbright BL 

PROVIDER: S-EPMC4250849 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature