Exploiting dependencies of pairwise comparison outcomes to predict patterns of gene response.

ABSTRACT:

Background

The analysis of gene expression has played an important role in medical and bioinformatics research. Although it is known that a large number of samples is needed to determine the patterns of gene expression accurately, practical designs of gene expression studies occasionally have insufficient numbers of samples, making it difficult to ascertain true response patterns of variantly expressed genes.

Results

We describe an approach to cope with the challenge of predicting true orders of gene response to treatments. We show that true patterns of gene response must be orderable sets. In experiments with few samples, we modify the conventional pairwise comparison tests and increase the significance level α intelligently to deduce orderable patterns, which are most like

SUBMITTER: Vo NS 

PROVIDER: S-EPMC4251046 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature