A lack of association between the CRP rs2794520 polymorphism and coronary artery disease.

ABSTRACT: Coronary artery disease (CAD) is mainly caused by atherosclerosis, which is closely associated with the C-reactive protein (CRP), a systemic inflammatory mediator. The aim of the present study was to examine whether the CRP rs2794520 polymorphism played a role in the risk of CAD. A total of 459 CAD patients and 432 non-CAD controls were recruited in the case-control study. Genotyping was performed on the SEQUENOM^® Mass-ARRAY iPLEX^® platform according to the manufacturer's instructions. The results showed that CRP rs2794520 was not associated with CAD. A further breakdown analysis by age or gender also indicated a lack of association between rs2794520 and CAD. In addition, the CRP rs2794520 polymorphism was not associated with the severity of CAD,

SUBMITTER: Lian J 

PROVIDER: S-EPMC4251100 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature