A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

ABSTRACT:

Objectives

Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects.

Methods

We performed a two-stage meta-analysis on more than 78,000 participants. In stage 1, we synthesised data from eight GWAS whereas data from 10 centres were used for 'in silico' or 'de novo' replication. Besides the main analysis, a stratified by sex analysis was performed to detect possible sex-specific signals. Meta-analysis was performed using inverse-variance fixed effects models. A random effects approach was also used.

Results

We accumulated 11,277 cases of radiographic and symptomatic hip OA. We prioritised eight single

SUBMITTER: Evangelou E 

PROVIDER: S-EPMC4251181 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature