Amelioration of experimental arthritis by stroke-induced immunosuppression is independent of Treg cell function.

ABSTRACT:

Objectives

Clinical evidence suggests that neurological lesions can protect from arthritis. Acute cerebral ischaemia induces severe immunosuppression, resulting in enhanced susceptibility to infections. We aimed to determine if stroke-induced immunosuppression can ameliorate arthritis and to delineate the immunological mechanisms involved.

Methods

Unilateral cerebral ischaemia was induced in mice by occlusion of one middle cerebral artery (MCAO) at different time points after induction of G6PI-induced arthritis in mice. Clinical and histological signs of arthritis were assessed. Regulatory T cells were specifically depleted by injection of diphtheria toxin into transgenic DEREG mice. Immunological correlates of MCAO were determined by flow cytometry and serological methods.<

SUBMITTER: Irmler IM 

PROVIDER: S-EPMC4251182 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature