Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron.

ABSTRACT: In multiple sclerosis (MS), diffuse degenerative processes in the deep grey matter have been associated with clinical disabilities. We performed a systematic study in MS deep grey matter with a focus on the incidence and topographical distribution of lesions in relation to white matter and cortex in a total sample of 75 MS autopsy patients and 12 controls. In addition, detailed analyses of inflammation, acute axonal injury, iron deposition and oxidative stress were performed. MS deep grey matter was affected by two different processes: the formation of focal demyelinating lesions and diffuse neurodegeneration. Deep grey matter demyelination was most prominent in the caudate nucleus and hypothalamus and could already be seen in early MS stages. Lesions developed on the background of inflamm

SUBMITTER: Haider L 

PROVIDER: S-EPMC4251183 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature