Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation.

ABSTRACT:

Objective

The dysfunction of immune regulation plays a critical role in the pathogenesis of a number of chronic inflammatory disorders, such as IBD. A close relationship between psychological stress and intestinal inflammation has been noted; the underlying mechanism remains elusive. This study aims to elucidate a pathological pathway between psychological stress and the dysfunction of regulatory T cells (Treg), and its effect on facilitating intestinal inflammation.

Design

A restraint stress model was employed to induce psychological stress in mice. The functions of Tregs were determined by assessing the immune suppressor effects in the intestine. A mouse model of intestinal inflammation was established using a low dose of trinitrobenzene sulfonic acid (TNBS) or dextran sul

SUBMITTER: Wu W 

PROVIDER: S-EPMC4251191 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature