Predicting survival in malignant pleural effusion: development and validation of the LENT prognostic score.

ABSTRACT:

Background

Malignant pleural effusion (MPE) causes debilitating breathlessness and predicting survival is challenging. This study aimed to obtain contemporary data on survival by underlying tumour type in patients with MPE, identify prognostic indicators of overall survival and develop and validate a prognostic scoring system.

Methods

Three large international cohorts of patients with MPE were used to calculate survival by cell type (univariable Cox model). The prognostic value of 14 predefined variables was evaluated in the most complete data set (multivariable Cox model). A clinical prognostic scoring system was then developed and validated.

Results

Based on the results of the international data and the multivariable survival analysis, the LENT prognostic score (ple

SUBMITTER: Clive AO 

PROVIDER: S-EPMC4251306 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature