Effect of CPAP on blood pressure in patients with minimally symptomatic obstructive sleep apnoea: a meta-analysis using individual patient data from four randomised controlled trials.

ABSTRACT:

Background

CPAP reduces blood pressure (BP) in patients with symptomatic obstructive sleep apnoea (OSA). Whether the same benefit is present in patients with minimally symptomatic OSA is unclear, thus a meta-analysis of existing trial data is required.

Methods

The electronic databases Medline, Embase and trial registries were searched. Trials were eligible if they included patients with minimally symptomatic OSA, had randomised them to receive CPAP or either sham-CPAP or no CPAP, and recorded BP at baseline and follow-up. Individual participant data were obtained. Primary outcomes were absolute change in systolic and diastolic BP.

Findings

Five eligible trials were found (1219 patients) from which data from four studies (1206 patients) were obtained. Mean (SD) baselin

SUBMITTER: Bratton DJ 

PROVIDER: S-EPMC4251445 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature