PET imaging of chemokine receptors in vascular injury-accelerated atherosclerosis.

ABSTRACT:

Unlabelled

Atherosclerosis is the pathophysiologic process behind lethal cardiovascular diseases. It is a chronic inflammatory progression. Chemokines can strongly affect the initiation and progression of atherosclerosis by controlling the trafficking of inflammatory cells in vivo through interaction with their receptors. Some chemokine receptors have been reported to play an important role in plaque development and stability. However, the diagnostic potential of chemokine receptors has not yet been explored. The purpose of this study was to develop a positron emitter-radiolabeled probe to image the upregulation of chemokine receptor in a wire-injury-accelerated apolipoprotein E knockout (ApoE(-/-)) mouse model of atherosclerosis.

Methods

A viral macrophage inflammatory prot

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4251467 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature