The effects of HIV-1 subtype and ethnicity on the rate of CD4 cell count decline in patients naive to antiretroviral therapy: a Canadian-European collaborative retrospective cohort study.

ABSTRACT:

Background

Ethnic differences have the potential to confound associations between HIV-1 subtype and immunologic progression. We compared declines in CD4 cell counts during untreated infection for the most prevalent HIV-1 subtypes, focusing on distinguishing between the effects of viral subtype and ethnicity.

Methods

We combined data from 4 European and 6 Canadian cohorts, selecting adults in the stable chronic phase of untreated HIV infection. We estimated the change in square root CD4 cell count over time for subtypes and ethnicities using mixed models, adjusting for covariates selected for their potential effect on initial CD4 cell count or its decline.

Results

Data from 9772 patients were analyzed, contributing 79 175 measurements of CD4 cell count and 24 157 perso

SUBMITTER: Klein MB 

PROVIDER: S-EPMC4251518 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature