Clinical utility of fixed-dose combinations in hypertension: evidence for the potential of nebivolol/valsartan.

ABSTRACT: Despite significant advances in pharmacologic approaches to treat hypertension during the last decades, hypertension- and hypertension-related organ damage are still a high health and economic burden because a large proportion of patients with hypertension do not achieve optimal blood pressure control. There is now general agreement that combination therapy with two or more antihypertensive drugs is required for targeted blood pressure accomplishment and reduction of global cardiovascular risk. The goals of combination therapies are to reduce long-term cardiovascular events by targeting different mechanism underlying hypertension and target organ disease, to block the counterregulatory pathways activated by monotherapies, to improve tolerability and decrease the adverse effects of up-titra

SUBMITTER: Varagic J 

PROVIDER: S-EPMC4251532 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature