The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study.

ABSTRACT:

Objective

Variation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA). We examined the role of the FTO polymorphism rs8044769 in risk of knee and hip OA in cases and controls incorporating body mass index (BMI) information.

Methods

5409 knee OA patients, 4355 hip OA patients and up to 5362 healthy controls from 7 independent cohorts from the UK and Australia were genotyped for rs8044769. The association of the FTO variant with OA was investigated in case/control analyses with and without BMI adjustment and in analyses matched for BMI category. A mendelian randomisation approach was employed using the FTO variant as the instrumental variable to evaluate t

SUBMITTER: Panoutsopoulou K 

PROVIDER: S-EPMC4251538 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature