Increased risk of radiographic emphysema in HIV is associated with elevated soluble CD14 and nadir CD4.

ABSTRACT:

Background

The association between HIV and emphysema remains incompletely understood. We sought to determine whether HIV is an independent risk factor for emphysema severity and whether markers of HIV severity and systemic biomarkers of inflammation (IL-6), altered coagulation (D-dimer), and immune activation (soluble CD14) are associated with emphysema.

Methods

We performed a cross-sectional analysis of 114 participants with HIV infection and 89 participants without HIV infection in the Examinations of HIV-Associated Lung Emphysema (EXHALE) study. Participants underwent chest CT imaging with blinded semiquantitative interpretation of emphysema severity, distribution, and type. We generated multivariable logistic regression models to determine the risk of HIV for radiographi

SUBMITTER: Attia EF 

PROVIDER: S-EPMC4251616 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature