Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones.

ABSTRACT: Dihydropyrimidones are an important class of biologically active heterocycles accessible from the multicomponent Biginelli condensation. Further manipulation of the dihydropyrimidone skeleton gives access to unique heterocycles. Presented herein is a Au-catalyzed cyclization of alkyne-tethered dihydropyrimidones to yield pyridopyrimidones.

SUBMITTER: Brown LE 

PROVIDER: S-EPMC4251731 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature