Effects of Systane(®) Balance on noninvasive tear film break-up time in patients with lipid-deficient dry eye.

ABSTRACT:

Purpose

To evaluate the ability of Systane(®) Balance (SYSB) administered four times per day for 4 weeks to increase noninvasive tear film break-up time (NITFBUT) over baseline compared with a saline (SAL) control in patients with lipid-deficient dry eye (DE).

Patients and methods

Patients aged ≥18 years with DE and evidence of meibomian gland dysfunction (ie, abnormal gland expression and missing meibomian glands) were included in this randomized, parallel-group, controlled, investigator-masked comparison study. Patients were randomized to SYSB or SAL four times daily for 4 weeks. The primary efficacy variable was mean change in NITFBUT from baseline at week 4. Ocular surface staining, goblet cell density, and meibomian gland expression were also assessed. Safety assessment

SUBMITTER: Aguilar AJ 

PROVIDER: S-EPMC4251748 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature