1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer.

ABSTRACT:

Background

The clinical behaviour of colon cancer is heterogeneous. Five-year overall survival is 50-65% with all stages included. Recurring somatic chromosomal alterations have been identified and some have shown potential as markers for dissemination of the tumour, which is responsible for most colon cancer deaths. We investigated 115 selected stage II-IV primary colon cancers for associations between chromosomal alterations and tumour dissemination.

Methods

Follow-up was at least 5 years for stage II-III patients without distant recurrence. Affymetrix SNP 6.0 microarrays and allele-specific copy number analysis were used to identify chromosomal alterations. Fisher's exact test was used to associate alterations with tumour dissemination, detected at diagnosis (stage IV) or

SUBMITTER: Mayrhofer M 

PROVIDER: S-EPMC4251789 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature