Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection in rodent models.

ABSTRACT:

Background

The emerging resistance of Plasmodium species to currently available anti-malarials remains a public health concern, hence the need for new effective, safe and affordable drugs. Natural products remain a reliable source of drugs. Nefang is a polyherbal anti-malarial of the Cameroonian folklore medicine with demonstrated in vitro antiplasmodial and antioxidant activities. It is composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, Ocimum gratissimum (leaves). This study aimed at investigating the suppressive, prophylactic and curative activities of Nefang in Plasmodium infected rodent models.

Methods

Systemic acute oral toxicity of Nefang aqueous and ethanol extracts was assessed in mice up to a dose of

SUBMITTER: Tarkang PA 

PROVIDER: S-EPMC4251988 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature