A simple peak detection and label-free quantitation algorithm for chromatography-mass spectrometry.

ABSTRACT:

Background

Label-free quantitation of mass spectrometric data is one of the simplest and least expensive methods for differential expression profiling of proteins and metabolites. The need for high accuracy and performance computational label-free quantitation methods is still high in the biomarker and drug discovery research field. However, recent most advanced types of LC-MS generate huge amounts of analytical data with high scan speed, high accuracy and resolution, which is often impossible to interpret manually. Moreover, there are still issues to be improved for recent label-free methods, such as how to reduce false positive/negatives of the candidate peaks, how to expand scalability and how to enhance and automate data processing. AB3D (A simple label-free quantitation algori

SUBMITTER: Aoshima K 

PROVIDER: S-EPMC4252003 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature