A matter of timing: identifying significant multi-dose radiotherapy improvements by numerical simulation and genetic algorithm search.

ABSTRACT: Multi-dose radiotherapy protocols (fraction dose and timing) currently used in the clinic are the product of human selection based on habit, received wisdom, physician experience and intra-day patient timetabling. However, due to combinatorial considerations, the potential treatment protocol space for a given total dose or treatment length is enormous, even for relatively coarse search; well beyond the capacity of traditional in-vitro methods. In constrast, high fidelity numerical simulation of tumor development is well suited to the challenge. Building on our previous single-dose numerical simulation model of EMT6/Ro spheroids, a multi-dose irradiation response module is added and calibrated to the effective dose arising from 18 independent multi-dose treatment programs available in the e

SUBMITTER: Angus SD 

PROVIDER: S-EPMC4252029 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature