Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets.

ABSTRACT:

Unlabelled

Hypothermia is ineffective in 45% of neonates with hypoxic-ischemic encephalopathy. Xenon has additive neuroprotective properties, but is expensive, and its application complicated. Argon gas is cheaper, easier to apply, and also has neuroprotective properties in experimental settings. The aim was to explore the safety of argon ventilation in newborn piglets.

Methods

Eight newborn piglets (weight 1.4-3.0 kg) were used. Heart rate, blood pressure, regional cerebral saturation, and electrocortical brain activity were measured continuously. All experiments had a 30 min. baseline period, followed by three 60 min. periods of argon ventilation alternated with 30 min argon washout periods. Two animals were ventilated with increasing concentrations of argon (1h 30%, 1 h 5

SUBMITTER: Alderliesten T 

PROVIDER: S-EPMC4252035 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature