Lifecourse relationship between maternal smoking during pregnancy, birth weight, contemporaneous anthropometric measurements and bone mass at 18years old. The 1993 Pelotas Birth Cohort.

ABSTRACT:

Background

Maternal smoking during pregnancy is associated with short-term and also long-term harmful effects on offspring.

Objective

The aim of this study is to evaluate the associations of maternal smoking during pregnancy with offspring bone health at 18years old, and the role of birth weight and contemporaneous height, weight and body mass index (BMI) in this association. Data from the 1993 Pelotas Birth Cohort were analyzed using path analysis stratified by sex. Adolescents at 18 years old (N=1512 males, 1563 females). DXA-determined total body bone mineral density (BMD) and bone mineral content (BMC) were assessed at 18 years old.

Results

Each additional cigarette smoked during pregnancy was associated with a lower BMC by -4.20 g in males (95% CI -8.37; -0.05),

SUBMITTER: Martinez-Mesa J 

PROVIDER: S-EPMC4252063 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature