Several genes encoding enzymes with the same activity are necessary for aerobic fungal degradation of cellulose in nature.

ABSTRACT: The cellulose-degrading fungal enzymes are glycoside hydrolases of the GH families and lytic polysaccharide monooxygenases. The entanglement of glycoside hydrolase families and functions makes it difficult to predict the enzymatic activity of glycoside hydrolases based on their sequence. In the present study we further developed the method Peptide Pattern Recognition to an automatic approach not only to find all genes encoding glycoside hydrolases and lytic polysaccharide monooxygenases in fungal genomes but also to predict the function of the genes. The functional annotation is an important feature as it provides a direct route to predict function from primary sequence. Furthermore, we used Peptide Pattern Recognition to compare the cellulose-degrading enzyme activities encoded by 39 fung

SUBMITTER: Busk PK 

PROVIDER: S-EPMC4252092 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature