Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression.

ABSTRACT:

Background

Adolescent depression is a common neuropsychiatric disorder that often continues into adulthood and is associated with a wide range of poor outcomes including suicide. Although numerous studies have looked at genetic markers associated with depression, the role of epigenetic variation remains relatively unexplored.

Methods

Monozygotic (MZ) twins were selected from an adolescent twin study designed to investigate the interplay of genetic and environmental factors in the development of emotional and behavioral difficulties. There were 18 pairs of MZ twins identified in which one member scored consistently higher (group mean within the clinically significant range) on self-rated depression than the other. We assessed genome-wide patterns of DNA methylation in twin bu

SUBMITTER: Dempster EL 

PROVIDER: S-EPMC4252163 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature