Antidepressants for cognitive impairment in schizophrenia--a systematic review and meta-analysis.

ABSTRACT:

Background

Cognitive impairment in schizophrenia is disabling, but current treatment options remain limited.

Objective

To meta-analyze the efficacy and safety of adjunctive antidepressants for cognitive impairment in schizophrenia.

Data sources and study selection

PubMed, MEDLINE, PsycINFO, and Cochrane Library databases were searched until 12/2013 for randomized controlled trials comparing antidepressant augmentation of antipsychotics with placebo regarding effects on cognitive functioning in schizophrenia.

Data extraction

Two authors independently extracted data. Standardized mean differences (SMDs) were calculated for continuous outcomes and risk ratios for categorical outcomes. SMDs of individual cognitive tests were pooled on a study level within domains (

SUBMITTER: Vernon JA 

PROVIDER: S-EPMC4252251 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature