Serum metabolomic profiling in acute alcoholic hepatitis identifies multiple dysregulated pathways.

ABSTRACT:

Background and objectives

While animal studies have implicated derangements of global energy homeostasis in the pathogenesis of acute alcoholic hepatitis (AAH), the relevance of these findings to the development of human AAH remains unclear. Using global, unbiased serum metabolomics analysis, we sought to characterize alterations in metabolic pathways associated with severe AAH and identify potential biomarkers for disease prognosis.

Methods

This prospective, case-control study design included 25 patients with severe AAH and 25 ambulatory patients with alcoholic cirrhosis. Serum samples were collected within 24 hours of the index clinical encounter. Global, unbiased metabolomics profiling was performed. Patients were followed for 180 days after enrollment to determine surviv

SUBMITTER: Rachakonda V 

PROVIDER: S-EPMC4252257 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature